Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

[HTML][HTML] Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric …

L Lu, Y Zhao, M Li, X Wang, J Zhu, L Liao… - Journal of Pharmaceutical …, 2024 - Elsevier
Extracellular polymeric substances (EPS) constitutes crucial elements within bacterial
biofilms, facilitating accelerated antimicrobial resistance and conferring defense against the …

Crisis averted: a world united against the menace of multiple drug-resistant superbugs-pioneering anti-AMR vaccines, RNA interference, nanomedicine, CRISPR …

U Saeed, RA Insaf, ZZ Piracha, MN Tariq… - Frontiers in …, 2023 - frontiersin.org
The efficacy of antibiotics and other antimicrobial agents in combating bacterial infections
faces a grave peril in the form of antimicrobial resistance (AMR), an exceedingly pressing …

Bacterial persister cells and development of antibiotic resistance in chronic infections: an update

AP Kunnath, M Suodha Suoodh… - British Journal of …, 2024 - frontierspartnerships.org
The global issue of antimicrobial resistance poses significant challenges to public health.
The World Health Organization (WHO) has highlighted it as a major global health threat …

Exploring the Probiotic Potential of Bacteroides spp. Within One Health Paradigm

MA Tufail, RA Schmitz - Probiotics and Antimicrobial Proteins, 2024 - Springer
Probiotics are pivotal in maintaining or restoring the balance of human intestinal microbiota,
a crucial factor in mitigating diseases and preserving the host's health. Exploration into …

A generalizable Cas9/sgRNA prediction model using machine transfer learning with small high-quality datasets

DT Ham, TS Browne, PN Banglorewala… - Nature …, 2023 - nature.com
The CRISPR/Cas9 nuclease from Streptococcus pyogenes (SpCas9) can be used with
single guide RNAs (sgRNAs) as a sequence-specific antimicrobial agent and as a genome …

Enhanced Stable and Efficient of Dual‐Ligand Zirconium‐Based Metal‐Organic Frameworks for Synergistic Photodynamic Inactivation

J Xu, Z Ding, M Wang, G Wu, J Xie - Small, 2024 - Wiley Online Library
Porphyrins, known for generating toxic singlet oxygen (1O2) to combat bacteria, face
challenges such as hydrophilicity and limited lifespan and 1O2 yield. Conversely …

Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based on Quorum Sensing (QS) Signal-Response System and Innovative Non-Antibiotic …

E Juszczuk-Kubiak - International Journal of Molecular Sciences, 2024 - mdpi.com
One of the key mechanisms enabling bacterial cells to create biofilms and regulate crucial
life functions in a global and highly synchronized way is a bacterial communication system …

Phage-induced efflux down-regulation boosts antibiotic efficacy

S Kraus, ML Fletcher, U Łapińska, K Chawla… - PLoS …, 2024 - journals.plos.org
The interactions between a virus and its host vary in space and time and are affected by the
presence of molecules that alter the physiology of either the host or the virus. Determining …

Beyond antibiotics: CRISPR/Cas9 triumph over biofilm-associated antibiotic resistance infections

A Zuberi, N Ahmad, H Ahmad, M Saeed… - Frontiers in Cellular and …, 2024 - frontiersin.org
A complex structure known as a biofilm is formed when a variety of bacterial colonies or a
single type of cell in a group sticks to a surface. The extracellular polymeric compounds that …