Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in
the literature, there is still confusion regarding its pathogenesis and clinical significance …

Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …

Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and
has the medical community rapidly searching for answers. An estimated 100,000 individuals …

Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute
respiratory distress syndrome (ARDS) being the most severe form of ALI and having a …

Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

Malignant glioblastoma (GBM) is prone to relapse due to the inevitable tumor cells residue
by surgery. During the tumor resection surgery in brain, addressing bleeding and superbug …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2019. Other selected articles can be found online at https://www …

Background Intravenous fluids, an essential component of sepsis resuscitation, may
paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models …