Astrocytes are the most numerous type of neuroglia in the brain and have a predominant
influence on the cerebrovascular system; they control perivascular homeostasis, the integrity …

The swelling-activated anion channel VRAC has fascinated and frustrated physiologists
since it was first described in 1988. Multiple laboratories have defined VRAC's biophysical …

Taurine is considered the most abundant free amino acid in the brain. Even though there are
endogenous mechanisms for taurine production in neural cells, an exogenous supply of …

Introduction Astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4
(TRPV4) channels form a functional complex that likely influences cell volume regulation …

Brain swelling is one of the most robust predictors of outcome following brain injury,
including ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the …

The volume-regulated anion channel (VRAC) is a key player in the volume regulation of
vertebrate cells. This ubiquitously expressed channel opens upon osmotic cell swelling and …

Despite of the major role of aquaporin (AQP) water channels in controlling transmembrane
water fluxes, alternative ways for modulating water permeation have been proposed. In the …

Astrocytes are non‐neuronal cells that govern the homeostatic regulation of the brain
through ions and water transport, and Ca2+‐mediated signaling. As they are tightly …

Astrocytes are the most abundant cell type in the CNS (central nervous system). They exert
multiple functions during development and in the adult CNS that are essential for brain …

Given the important functions that glutamate serves in excitatory neurotransmission,
understanding the regulation of glutamate in physiological and pathological states is critical …