The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-
genome and exome sequencing followed by innovative tumorgraft analyses (to accurately …

Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous
developmental genes. To silence or activate gene expression, respectively, PcG and trxG …

Cells employ elaborate mechanisms to introduce structural and chemical variation into
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …

The plasticity of ageing suggests that longevity may be controlled epigenetically by specific
alterations in chromatin state. The link between chromatin and ageing has mostly focused …

The transcription factor Snail has been described as a direct repressor of E-cadherin
expression during development and carcinogenesis; however, the specific mechanisms …

O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …

Abstract Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with
transcription activation. A common feature of several H3K4 methyltransferase complexes is …

Summary O-linked N-acetylglucosamine (O-GlcNAc) transferase (Ogt) activity is essential for
embryonic stem cell (ESC) viability and mouse development. Ogt is present both in the …