Wilson disease (WD) is a potentially treatable, inherited disorder of copper metabolism that
is characterized by the pathological accumulation of copper. WD is caused by mutations in …

Epigenetics is a rapidly growing field that studies gene expression modifications not
involving changes in the DNA sequence. Histone H3, one of the basic proteins in the …

As emerging contaminants, microplastics (MPs) are predicted to act as vectors for other
contaminants and their combined effects are largely unknown. In this study, the combined …

To develop potential next-generation metal anticancer agents, we designed and
synthesised five Cu (II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen …

Methionine adenosyltransferases (MATs) are the family of enzymes that synthesize the main
biological methyl donor, S-adenosylmethionine. The high sequence conservation among …

Wilson's disease (WD) is a rare, autosomal recessive disorder of copper metabolism caused
by pathogenic mutations in the ATP7B gene. Cellular copper overload is associated with …

Wilson disease (WD) is a complex condition due to copper accumulation mainly in the liver
and brain. The genetic base of WD is represented by pathogenic mutations of the copper …

Hepatic methionine metabolism may play an essential role in regulating methylation status
and liver injury in Wilson's disease (WD) through the inhibition of S‐adenosylhomocysteine …

Steatohepatitis (SH) is an intermediate stage of fatty liver disease and is one of the most
common causes of chronic liver disease worldwide that may progress to cirrhosis and liver …

Nutritional imbalance is emerging as a causative factor of hearing loss. Epidemiologic
studies have linked hearing loss to elevated plasma total homocysteine (tHcy) and folate …