MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy

AM Cornel, IL Mimpen, S Nierkens - Cancers, 2020 - mdpi.com
In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications

K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …

The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers

Y Risha, Z Minic, SM Ghobadloo, MV Berezovski - Scientific reports, 2020 - nature.com
Cancer cells release small extracellular vesicles, exosomes, that have been shown to
contribute to various aspects of cancer development and progression. Differential analysis of …

miRNAs as biomarkers for early cancer detection and their application in the development of new diagnostic tools

LJ Galvão-Lima, AHF Morais, RAM Valentim… - Biomedical engineering …, 2021 - Springer
Over the last decades, microRNAs (miRNAs) have emerged as important molecules
associated with the regulation of gene expression in humans and other organisms …

CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p

D Rong, C Lu, B Zhang, K Fu, S Zhao, W Tang, H Cao - Molecular cancer, 2019 - Springer
Abstract Background Circular RNAs (circRNAs) are a class of non-coding RNAs with a loop
structure, but its functions remain largely unknown. Growing evidence has revealed that …

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

XZ Zhou, KP Lu - Nature Reviews Cancer, 2016 - nature.com
Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

Y Chen, Y Wu, H Yang, X Li, M Jie, C Hu, Y Wu… - Cell Death & …, 2018 - nature.com
Pin1 is the only known peptidyl-prolyl cis–trans isomerase (PPIase) that specifically
recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) …

MicroRNAs in prostate cancer: Functional role as biomarkers

R Kanwal, AR Plaga, X Liu, GC Shukla, S Gupta - Cancer Letters, 2017 - Elsevier
MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene
expression through post-transcriptional regulation of messenger RNA. Compelling evidence …

Gene expression profile of the clinically aggressive micropapillary variant of bladder cancer

CC Guo, V Dadhania, LI Zhang, T Majewski… - European urology, 2016 - Elsevier
Background Progression of conventional urothelial carcinoma of the bladder to a tumor with
unique microscopic features referred to as micropapillary carcinoma is coupled with …

Molecular crosstalk between cancer and neurodegenerative diseases

J Seo, M Park - Cellular and Molecular Life Sciences, 2020 - Springer
The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …