Nanodiscs in membrane biochemistry and biophysics

IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

High-density lipoprotein heterogeneity and function in reverse cholesterol transport

GH Rothblat, MC Phillips - Current opinion in lipidology, 2010 - journals.lww.com
High-density lipoprotein heterogeneity and function in rever... : Current Opinion in Lipidology
High-density lipoprotein heterogeneity and function in reverse cholesterol transport : Current …

Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters

B György, K Módos, E Pállinger… - Blood, The Journal …, 2011 - ashpublications.org
Numerous diseases, recently reported to associate with elevated microvesicle/microparticle
(MP) counts, have also long been known to be characterized by accelerated immune …

Crystal structure of C-terminal truncated apolipoprotein AI reveals the assembly of high density lipoprotein (HDL) by dimerization

X Mei, D Atkinson - Journal of Biological Chemistry, 2011 - ASBMB
Apolipoprotein AI (apoA-I) plays important structural and functional roles in plasma high
density lipoprotein (HDL) that is responsible for reverse cholesterol transport. However, a …

Methionine oxidation impairs reverse cholesterol transport by apolipoprotein AI

B Shao, G Cavigiolio, N Brot… - Proceedings of the …, 2008 - National Acad Sciences
HDL protects against vascular disease by accepting free cholesterol from macrophage foam
cells in the artery wall. This pathway is critically dependent on lecithin: cholesterol …

Diabetes impairs cellular cholesterol efflux from ABCA1 to small HDL particles

Y He, GE Ronsein, C Tang, GP Jarvik… - Circulation …, 2020 - Am Heart Assoc
Rationale: HDL (high-density lipoprotein) may be cardioprotective because it accepts
cholesterol from macrophages via the cholesterol transport proteins ABCA1 (ATP-binding …

Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy [S]

L Zhang, J Song, G Cavigiolio, BY Ishida, S Zhang… - Journal of lipid …, 2011 - ASBMB
Plasma lipoprotein levels are predictors of risk for coronary artery disease. Lipoprotein
structure-function relationships provide important clues that help identify the role of …

Quantification of HDL particle concentration by calibrated ion mobility analysis

PM Hutchins, GE Ronsein, JS Monette… - Clinical …, 2014 - academic.oup.com
BACKGROUND It is critical to develop new metrics to determine whether HDL is
cardioprotective in humans. One promising approach is HDL particle concentration (HDL-P) …

Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers [S]

MG Sorci-Thomas, JS Owen, B Fulp, S Bhat, X Zhu… - Journal of lipid …, 2012 - ASBMB
This report details the lipid composition of nascent HDL (nHDL) particles formed by the
action of the ATP binding cassette transporter A1 (ABCA1) on apolipoprotein AI (apoA-I) …

Flipped C-terminal ends of apoA1 promote ABCA1-dependent cholesterol efflux by small HDLs

Y He, C Pavanello, PM Hutchins, C Tang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …