TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
TRPV4 as a therapeutic target for joint diseases
Biomechanical factors play a critical role in regulating the physiology as well as the
pathology of multiple joint tissues and have been implicated in the pathogenesis of …
pathology of multiple joint tissues and have been implicated in the pathogenesis of …
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading
CJ O'conor, HA Leddy, HC Benefield… - Proceedings of the …, 2014 - National Acad Sciences
Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …
Enhancement of mesenchymal stem cell chondrogenesis with short-term low intensity pulsed electromagnetic fields
Pulse electromagnetic fields (PEMFs) have been shown to recruit calcium-signaling
cascades common to chondrogenesis. Here we document the effects of specified PEMF …
cascades common to chondrogenesis. Here we document the effects of specified PEMF …
Tension stimulation drives tissue formation in scaffold-free systems
Scaffold-free systems have emerged as viable approaches for engineering load-bearing
tissues. However, the tensile properties of engineered tissues have remained far below the …
tissues. However, the tensile properties of engineered tissues have remained far below the …
Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: Potential therapeutic targets for osteoarthritis
K Zhang, L Wang, Z Liu, B Geng, Y Teng, X Liu, Q Yi… - Channels, 2021 - Taylor & Francis
Articular cartilage consists of an extracellular matrix including many proteins as well as
embedded chondrocytes. Articular cartilage formation and function are influenced by …
embedded chondrocytes. Articular cartilage formation and function are influenced by …
TRPV4 and PIEZO channels mediate the mechanosensing of chondrocytes to the biomechanical microenvironment
M Zhang, N Meng, X Wang, W Chen, Q Zhang - Membranes, 2022 - mdpi.com
Articular cartilage and their chondrocytes are physiologically submitted to diverse types of
mechanical cues. Chondrocytes produce and maintain the cartilage by sensing and …
mechanical cues. Chondrocytes produce and maintain the cartilage by sensing and …
Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation
channel that is highly expressed in cartilage and is sensitive to a variety of extracellular …
channel that is highly expressed in cartilage and is sensitive to a variety of extracellular …
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage
X Li, Y Lu, Y Wang, S Zhou, L Li, F Zhao - Drug Delivery, 2021 - Taylor & Francis
In the human body, joint cartilage is of great importance. It has long been a big therapeutic
problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories …
problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories …
Polymodal transient receptor potential vanilloid (TRPV) ion channels in chondrogenic cells
C Szűcs Somogyi, C Matta, Z Foldvari… - International journal of …, 2015 - mdpi.com
Mature and developing chondrocytes exist in a microenvironment where mechanical load,
changes of temperature, osmolarity and acidic pH may influence cellular metabolism …
changes of temperature, osmolarity and acidic pH may influence cellular metabolism …