The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

During development of TGF-β1-initiated fibroproliferative disorders, NADPH oxidases (NOX
family members) generate reactive oxygen species (ROS) resulting in downstream …

Fibrotic disorders of the renal, pulmonary, cardiac, and hepatic systems are associated with
significant morbidity and mortality. Effective therapies to prevent or curtail the advancement …

Obstructive nephropathy is a major cause of renal failure, particularly in newborn babies and
children. After urinary tract obstruction, and under the influence of mechanical forces and …

Background/Aims: Since renal fibrosis always predisposes end-stage renal disease,
elucidation of the molecular mechanisms that underlie the progression of renal fibrosis may …

Chronic kidney disease constitutes an increasing medical burden affecting 26 million people
in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological …

Renal fibrosis is the fundamental pathway leading to end-stage renal disease, while its
exact molecular basis remains incompletely elucidated. Previous studies have …

Background It is well established that renin-angiotensin system (RAS) play a central role in
pathophysiology of renal damage following unilateral ureteral obstruction (UUO). The …

Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute
kidney injury, indicating that it constitutes a component of the endogenous stress response …

Vitamin D slows the progression of chronic kidney disease. Furthermore, activators of
vitamin D receptors (VDR) have suppressant effects on the renin-angiotensin system, as …