Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

Cells reprogram gene expression in response to environmental changes by mobilizing
transcriptional activators. The activator protein Gcn4 of the yeast Saccharomyces cerevisiae …

During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene
expression designed to ameliorate the underlying cellular disturbance. Central to this stress …

Selection of the translational initiation site in most eukaryotic mRNAs appears to occur via a
scanning mechanism which predicts that proximity to the 5′ end plays a dominant role in …

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of
human APCs that express indoleamine 2, 3-dioxygenase (IDO) and inhibit T cell …

Productive herpesvirus infection requires a profound, time-controlled remodeling of the viral
transcriptome and proteome. To gain insights into the genomic architecture and gene …

The mechanism of initiation of translation differs between prokaryotes and eukaryotes, and
the strategies used for regulation differ accordingly. Translation in prokaryotes is usually …

Changes in gene expression are at the core of most biological processes, from cell
differentiation to organ development, including the adaptation of the whole organism to the …

Protein synthesis is the ultimate step of gene expression and a key control point for
regulation. In particular, it enables cells to rapidly manipulate protein production without new …

Translation regulation plays important roles in both normal physiological conditions and
diseases states. This regulation requires cis‐regulatory elements located mostly in 5′ and …