Atherosclerosis is a leading cause of cardiovascular disease worldwide, and
hypercholesterolemia is a major risk factor. Preventive treatments mainly focus on the …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …

Uncontrolled regeneration leads to neoplastic transformation,–. The intestinal epithelium
requires precise regulation during continuous homeostatic and damage-induced tissue …

The discovery of adipose triglyceride lipase (ATGL) and its coactivator comparative gene
identification-58 (CGI-58) provided a major paradigm shift in the understanding of …

Probiotics effectively regulated lipid metabolism and improved hyperlipidemia. The purpose
of this study was to further evaluate the functions of lipid-lowering strains in vivo and …

The cholesterol efflux protein ATP binding cassette protein A1 (ABCA) and apolipoprotein
A1 (apo A1) are key constituents in the process of reverse-cholesterol transport (RCT) …

Efferocytosis is critical for tissue homeostasis, as its deregulation is associated with several
autoimmune pathologies. While engulfing apoptotic cells, phagocytes activate transcription …

Hypercholesterolemia drives the development of cardiovascular disease, Supplementation
with probiotics that interfere with cholesterol metabolism provide a contribution to disease …

The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they
regulate gene transcription and thereby mediate changes in metabolic pathways …

Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for
treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that …