Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers
AMS El-Sharief, YA Ammar, A Belal… - Bioorganic …, 2019 - Elsevier
Abstract Reaction of 5-morphilinosulfonylisatin (1) with acetophenones (2a–e) afforded 3-
hydroxy-3-substituted-2-oxoindoles 3a-e, when treated with acetic acid the expected 3 …
hydroxy-3-substituted-2-oxoindoles 3a-e, when treated with acetic acid the expected 3 …
Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study
SY Abbas, RAK Al-Harbi, MAMS El-Sharief - European Journal of …, 2020 - Elsevier
New thiourea derivatives bearing a benzodioxole moiety were synthesized via the reaction
of 5-isothiocyanatobenzodioxole with amino compounds such as aromatic amines, sulfa …
of 5-isothiocyanatobenzodioxole with amino compounds such as aromatic amines, sulfa …
One-pot synthesis and molecular docking of some new spiropyranindol-2-one derivatives as immunomodulatory agents and in vitro antimicrobial potential with DNA …
Abstract a series of 2-oxospiro [indoline-3, 4′-pyran] derivatives 4 and 7 were obtained in
good yield under mild conditions from the one-pot reaction of indole-2, 3-dione derivatives 1 …
good yield under mild conditions from the one-pot reaction of indole-2, 3-dione derivatives 1 …
The therapeutic journey of pyridazinone
Pyridazinones have drawn a substantial attention within the field of research analysis and
development. The moiety is a subject matter of intensive research because of its wide …
development. The moiety is a subject matter of intensive research because of its wide …
[HTML][HTML] Virtual screening in drug-likeness and structure/activity relationship of pyridazine derivatives as Anti-Alzheimer drugs
Virtual screening emerged as an important tool in our quest to access successful CNS
medicaments for treating Alzheimer's disease. The computational techniques applied in this …
medicaments for treating Alzheimer's disease. The computational techniques applied in this …
Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity
S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …
pharmacological activities. A large number of research articles and patents described them …
Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers
The cyclization of chalcones 3a-3u with 3-hydrazinyl-6-phenylpyridazine 7 under basic
condition led to the formation of new pyrazoline derivatives 8a-8u. All final compounds were …
condition led to the formation of new pyrazoline derivatives 8a-8u. All final compounds were …
Sulphonamides: Deserving class as MMP inhibitors?
P Jain, C Saravanan, SK Singh - European Journal of Medicinal Chemistry, 2013 - Elsevier
The importance of sulphonamide moiety in medicinal chemistry cannot be ignored as it
constitutes an important class of extensively used drugs. Recently, sulphonamides have …
constitutes an important class of extensively used drugs. Recently, sulphonamides have …