Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms
Y Wang, Y Zeng, W Yang, X Wang, J Jiang - Phytomedicine, 2024 - Elsevier
Background Despite significant advances in cancer immunotherapy over the past decades,
such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune …
such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune …
[HTML][HTML] Targeting Metabolic–Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy
Y Wang, J He, S Lian, Y Zeng, S He, J Xu, L Luo… - Antioxidants, 2024 - mdpi.com
Drug resistance is currently one of the biggest challenges in cancer treatment. With the
deepening understanding of drug resistance, various mechanisms have been revealed …
deepening understanding of drug resistance, various mechanisms have been revealed …
Identification of EMT-associated prognostic features among grade II/III gliomas
W Yang, L Lin, T Lu, H Yu, S Zhang - Scientific Reports, 2024 - nature.com
Grade II/III gliomas have a highly heterogeneous clinical course. Identifying prognostic
biomarkers in grade II/III gliomas is essential to guide clinical management. We explored …
biomarkers in grade II/III gliomas is essential to guide clinical management. We explored …
[HTML][HTML] ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition
J Yan, W Duan, Q Gao, T Mao, M Wang, J Duan… - Pharmacological …, 2023 - Elsevier
In our previous multicenter study, we delineated the inherent metabolic features of colorectal
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation
Abstract BRAF V600E attracts wide attention in the treatment of colorectal cancer (CRC) as
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …
Oxidative Stress Promotes Liver Cancer Metastasis via RNF25‐Mediated E‐Cadherin Protein Degradation
Z Huang, L Zhou, J Duan, S Qin, J Jiang… - Advanced …, 2024 - Wiley Online Library
Loss of E‐cadherin (ECAD) is required in tumor metastasis. Protein degradation of ECAD in
response to oxidative stress is found in metastasis of hepatocellular carcinoma (HCC) and is …
response to oxidative stress is found in metastasis of hepatocellular carcinoma (HCC) and is …
Identification and clinical validation of diverse cell-death patterns-associated prognostic features among low-grade gliomas
W Yang, H Yu, Q Lei, C Pu, Y Guo, L Lin - Scientific Reports, 2024 - nature.com
Low-grade glioma (LGG) is heterogeneous at biological and transcriptomic levels, and it is
still controversial for the definition and typing of LGG. Therefore, there is an urgent need for …
still controversial for the definition and typing of LGG. Therefore, there is an urgent need for …
FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma
L Luo, X Wu, J Fan, L Dong, M Wang, Y Zeng… - Nature …, 2024 - nature.com
Cancer cells are often addicted to serine synthesis to support growth. How serine synthesis
is regulated in cancer is not well understood. We recently demonstrated protein arginine …
is regulated in cancer is not well understood. We recently demonstrated protein arginine …
Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell …
J Ye, X Huang, S Tian, J Wang, H Wang, H Feng… - Experimental Cell …, 2024 - Elsevier
Serine metabolic reprogramming is known to be associated with oncogenesis and tumor
development. The key metabolic enzyme PSAT1 has been identified as a potential …
development. The key metabolic enzyme PSAT1 has been identified as a potential …
HSPA8 Activates Wnt/β-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation
L Bowen, M Hui, S Qin, L Zhou, Z Huang… - Advanced …, 2024 - search.proquest.com
Abstract BRAF V600E attracts wide attention in the treatment of colorectal cancer (CRC) as
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …
stratifying and predicting a refractory classification of CRC. Recent evidence indicates that …