[PDF][PDF] Iron overload disorders

CC Hsu, NH Senussi, KY Fertrin… - Hepatology …, 2022 - Wiley Online Library
Iron overload disorders represent a variety of conditions that lead to increased total body
iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron …

Molecular mechanisms of ferroptosis and its roles in hematologic malignancies

Y Zhao, Z Huang, H Peng - Frontiers in oncology, 2021 - frontiersin.org
Cell death is essential for the normal metabolism of human organisms. Ferroptosis is a
unique regulated cell death (RCD) mode characterized by excess accumulation of iron …

Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models

C Larrue, S Mouche, P Angelino, M Sajot… - Science Translational …, 2024 - science.org
Acute myeloid leukemia (AML) remains a challenging hematological malignancy with poor
prognosis and limited treatment options. Leukemic stem cells (LSCs) contribute to …

CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD

F Long, Z Lin, Q Long, Z Lu, K Zhu, M Zhao, M Yang - Cancers, 2023 - mdpi.com
Simple Summary It is urgent to identify new biomarkers for diagnosis, prognostication, and
therapeutic targets of acute myeloid leukemia (AML) so as to develop more effective …

Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway

R Sun, M Liu, K Xu, Y Pu, J Huang, J Liu… - Chemico-biological …, 2022 - Elsevier
Benzene is a pollutant that widely exists in the environment and in occupational workplaces.
Its exposure is closely associated with hematological disorders and even leukemia, which …

Probiotics ameliorate benzene-induced systemic inflammation and hematopoietic toxicity by inhibiting Bacteroidaceae-mediated ferroptosis

L Zhang, H Kang, W Zhang, JY Wang, Z Liu… - Science of The Total …, 2023 - Elsevier
The intestinal microbiota is associated with the development of benzene-induced
hematopoietic toxicity. Modulation of intestinal homeostasis by probiotic supplementation …

Construction and validation of a novel ferroptosis-related prognostic model for acute myeloid leukemia

Y Song, S Tian, P Zhang, N Zhang, Y Shen… - Frontiers in …, 2022 - frontiersin.org
Acute myeloid leukemia (AML) is a clonal malignant proliferative blood disorder with a poor
prognosis. Ferroptosis, a novel form of programmed cell death, holds great promise for …

Role of iron in aging related diseases

WJ Chen, GP Kung, JP Gnana-Prakasam - Antioxidants, 2022 - mdpi.com
Iron progressively accumulates with age and can be further exacerbated by dietary iron
intake, genetic factors, and repeated blood transfusions. While iron plays a vital role in …

Identification of TFRC as a biomarker for pulmonary arterial hypertension based on bioinformatics and experimental verification

C Yang, YH Liu, HK Zheng - Respiratory Research, 2024 - Springer
Background Pulmonary arterial hypertension (PAH) is a life-threatening chronic
cardiopulmonary disease. However, there is a paucity of studies that reflect the available …

Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation

J Styczyński, A Słomka, M Łęcka, K Albrecht… - Cancers, 2023 - mdpi.com
Simple Summary In children after intensive chemotherapy for acute leukemias (AL) or
undergoing hematopoietic cell transplantation (HCT), the prognostic impact of 12 serum iron …