Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

KCF Bordon, GA Wiezel, FG Amorim… - Journal of venomous …, 2015 - SciELO Brasil
Hyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan
of the interstitial matrix. They are involved in several pathological and physiological activities …

[HTML][HTML] Spider genomes provide insight into composition and evolution of venom and silk

KW Sanggaard, JS Bechsgaard, X Fang, J Duan… - Nature …, 2014 - nature.com
Spiders are ecologically important predators with complex venom and extraordinarily tough
silk that enables capture of large prey. Here we present the assembled genome of the social …

Hyaluronidases: a therapeutic enzyme

N Khan, ZR Niazi, FU Rehman, A Akhtar… - Protein and Peptide …, 2018 - benthamdirect.com
Background: Hyaluronidase is the most important enzyme found in the interstitial matrix,
effectively degrading the hyaluronic acid. Hyaluronidases are extensively found in the …

Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A2

I Vergara, M Pedraza-Escalona, D Paniagua… - Journal of …, 2014 - Elsevier
Here we show for the first time that the venom from an elapid (Micrurus fulvius) contains
three finger toxin (3FTxs) peptides with low toxicity but high content of lethal phospholipases …

Multiomics Profiling of Toxins in the Venom of the Amazonian Spider Acanthoscurria juruenicola

ES Nishiduka, TF Abreu, FM Abukawa… - Journal of Proteome …, 2022 - ACS Publications
Acanthoscurria juruenicola is an Amazonian spider described for the first time almost a
century ago. However, little is known about their venom composition. Here, we present a …

Molecular, Immunological, and Biological Characterization of Tityus serrulatus Venom Hyaluronidase: New Insights into Its Role in Envenomation

CCR Horta, BF Magalhaes… - PLoS neglected …, 2014 - journals.plos.org
Background Scorpionism is a public health problem in Brazil, and Tityus serrulatus (Ts) is
primarily responsible for severe accidents. The main toxic components of Ts venom are low …

Characterisation of protein families in spider digestive fluids and their role in extra-oral digestion

A Walter, J Bechsgaard, C Scavenius, TS Dyrlund… - BMC genomics, 2017 - Springer
Background Spiders are predaceous arthropods that are capable of subduing and
consuming relatively large prey items compared to their own body size. For this purpose …

Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins?

LH Gremski, FH Matsubara, HC Justa… - Journal of Venomous …, 2021 - SciELO Brasil
Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition
that often includes a threatening necrotic skin lesion near the bite site along with a …

Isolation, N-glycosylations and Function of a Hyaluronidase-Like Enzyme from the Venom of the Spider Cupiennius salei

O Biner, C Trachsel, A Moser, L Kopp… - PLoS …, 2015 - journals.plos.org
Structure of Cupiennius salei venom hyaluronidase Hyaluronidases are important venom
components acting as spreading factor of toxic compounds. In several studies this spreading …

cDNA Cloning, Heterologous Expression, Cytotoxicity, and Inhibitory Effects of a Disintegrin from Bothrops ammodytoides Venom

H Clement, LL Corrales-García… - International Journal of …, 2023 - Springer
An mRNA transcript that codes for a Disintegrin and a Metalloprotease from a venom gland
of the viper Bothrops ammodytoides was isolated. Vector pCR® 2.1-TOPO was used to …