Hydroamination, the addition of an N–H bond across a C–C multiple bond, is a reaction with
a great synthetic potential. Important advances have been made in the last decades …

The combination of chemo-and biocatalysis in one pot (integrated catalysis) is a powerful
approach to develop new routes towards important products under mild and environmentally …

Designing efficient enzymes is a formidable challenge at the forefront of modern
biocatalysis. Here, we review recent developments in the field and illustrate how the …

While natural terpenoid cyclases generate complex terpenoid structures via cationic
mechanisms, alternative radical cyclization pathways are underexplored. The metal …

Iron–sulfur clusters have been reported to catalyze various redox transformations, including
the multielectron reduction of CO2 to hydrocarbons. Herein, we report the design and …

The development of artificial metalloenzymes (ArMs) aims to expand the capabilities of
enzymatic catalysis, most notably towards new reaction mechanisms. Frequently, ArMs …

Artificial metalloenzymes (ArMs) are gaining much attention in life sciences. However, the
function of the present ArMs for disease treatment is still in its infancy, which may impede the …

Engineering dual‐function single polypeptide catalysts with two abiotic or biotic catalytic
entities (or combinations of both) supporting cascade reactions is becoming an important …

In this Perspective, we present progress, outstanding challenges, and opportunities for the
incorporation of artificial metalloenzymes (ArMs) into biosynthetic pathways. We first explain …

Tailored enzymes are crucial for the transition to a sustainable bioeconomy. However,
enzyme engineering is laborious and failure-prone due to its reliance on serendipity. The …