This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …

Sodium-dependent neutral amino acid transporter B 0 AT1 (SLC6A19) and imino acid
(proline) transporter SIT1 (SLC6A20) are expressed at the luminal membrane of small …

The SLC7 family is divided into two subgroups, the cationic amino acid transporters (the
CAT family, SLC7A1–4) and the glycoprotein-associated amino acid transporters (the gpaAT …

Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial
hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary …

The supply of arginine may become rate limiting for enzymatic reactions that use this
semiessential amino acid as a substrate (eg, nitric oxide, agmatine, creatine, and urea …

Recent developments in the genetics and physiology of cystinuria do not support the
traditional classification, which is based on the excretion of cystine and dibasic amino acids …

Cystinuria is a primary inherited aminoaciduria caused by mutations in the genes that
encode the two subunits (neutral and basic amino acid transport protein rBAT and b (0,+) …

The heteromeric amino acid transporters (HATs) are composed of a light and a heavy
subunit linked by a disulfide bridge. The heavy subunits are the SLC3 members (rBAT and …