Abstract In December 1997, the National Cancer Institute sponsored “The International
Workshop on Microsatellite Instability and RER Phenotypes in Cancer Detection and …

We have proposed that an early step in tumor progression is the expression of a mutator
phenotype resulting from mutations in genes that normally function in the maintenance of …

Alterations in gene sequences, expression levels and protein structure or function have
been associated with every type of cancer. These'molecular markers' can be useful in …

OBJECTIVES: To determine the clinical utility of urine-based bladder tumor markers
(UBBTMs) and cytology in the treatment of patients with transitional cell carcinoma on the …

This is the first of 2 articles that summarize the findings of the International Consensus Panel
on cytology and bladder tumor markers. The objectives of our panel were to reach a …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colorectal cancer and in a large number of …

Continued elucidation of the genetic changes that drive cancer progression is yielding new
and potentially powerful nucleic acid–based markers of neoplastic disease. Pilot studies …

Urinary monitoring of diseases has gained considerable attention due to its simple and non-
invasive sampling. However, urinalysis remains limited by the dearth of reliable urinary …

Combining whole genome amplification (WGA) methods with novel laser-based
microdissection techniques has made it possible to exploit recent progress in molecular …

Development of noninvasive methods for the diagnosis of transitional cell carcinoma (TCC)
of the bladder remains a challenge. A ProteinChip technology (surface enhanced laser …