NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2022 - pmc.ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …

Role of insulin resistance in MAFLD

Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

[HTML][HTML] A subset of Kupffer cells regulates metabolism through the expression of CD36

C Blériot, E Barreby, G Dunsmore, R Ballaire… - Immunity, 2021 - cell.com
Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …

Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease

S Lim, JW Kim, G Targher - Trends in Endocrinology & Metabolism, 2021 - cell.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition
characterized by hepatic fat accumulation combined with underlying metabolic …

Targeting mitochondrial ROS-mediated ferroptosis by quercetin alleviates high-fat diet-induced hepatic lipotoxicity

JJ Jiang, GF Zhang, JY Zheng, JH Sun… - Frontiers in …, 2022 - frontiersin.org
Background: The protective effect of quercetin on nonalcoholic fatty liver disease (NAFLD)
has been reported, but its mechanism remains poorly understood. Recently, quercetin was …

Di-2-ethylhexyl phthalate (DEHP) induced lipid metabolism disorder in liver via activating the LXR/SREBP-1c/PPARα/γ and NF-κB signaling pathway

YQ Huang, YX Tang, BH Qiu, M Talukder, XN Li… - Food and Chemical …, 2022 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) has been widely used in many fields (agricultural
products, medical instruments, and food packing). As an environmental contaminant, DEHP …

The role of tumor necrosis factor-alpha in the pathogenesis and treatment of nonalcoholic fatty liver disease

ID Vachliotis, SA Polyzos - Current obesity reports, 2023 - Springer
Abstract Purpose of Review To summarize experimental and clinical evidence on the
association between tumor necrosis factor-α (TNF-α) and nonalcoholic fatty liver disease …

Plasma free fatty acid concentration as a modifiable risk factor for metabolic disease

GC Henderson - Nutrients, 2021 - mdpi.com
Plasma free fatty acid (FFA) concentration is elevated in obesity, insulin resistance (IR), non-
alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and related comorbidities such …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …