Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …

Abstract Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide.
Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but the …

Metabolic diseases, including obesity, dyslipidemia, and type 2 diabetes, have become
severe challenges worldwide. The Developmental Origins of Health and Disease (DOHaD) …

Aims This study explores the correlation between site-specific methylation levels of the
KCNJ11 promoter and type 2 diabetes mellitus (T2DM), analyzing potential molecular …

A large proportion of skeletal muscle insulin resistance in type 2 diabetes (T2D) is caused by
environmental factors. By applying multiomics mRNA, microRNA (miRNA), and DNA …

Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has
become a global health concern with an increasing prevalence worldwide. The International …

The pathophysiological mechanisms of cardiovascular disease and microvascular
complications in diabetes have been extensively studied, but effective methods of …

ABSTRACT Aims, Patients & Methods Dietary factors may regulate the epigenome. We
aimed to explore whether a diet intervention, including excess sugar, affects the methylome …

Diabetes is a leading cause of global mortality and disability, and its economic burden is
substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all …