Astrocyte endfeet in brain function and pathology: open questions

B Díaz-Castro, S Robel, A Mishra - Annual Review of …, 2023 - annualreviews.org
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

The role of astrocytes in CNS inflammation

F Giovannoni, FJ Quintana - Trends in immunology, 2020 - cell.com
Astrocytes are the most abundant cell type in the central nervous system (CNS), performing
complex functions in health and disease. It is now clear that multiple astrocyte subsets or …

Identification of region-specific astrocyte subtypes at single cell resolution

MY Batiuk, A Martirosyan, J Wahis, F de Vin… - Nature …, 2020 - nature.com
Astrocytes, a major cell type found throughout the central nervous system, have general
roles in the modulation of synapse formation and synaptic transmission, blood–brain barrier …

Astrocytes and microglia: in sickness and in health

ID Vainchtein, AV Molofsky - Trends in neurosciences, 2020 - cell.com
Healthy central nervous system (CNS) development and function require an intricate and
balanced bidirectional communication between neurons and glia cells. In this review, we …

Beyond the GFAP-astrocyte protein markers in the brain

AM Jurga, M Paleczna, J Kadluczka, KZ Kuter - Biomolecules, 2021 - mdpi.com
The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The emerging nature of astrocyte diversity

BS Khakh, B Deneen - Annual review of neuroscience, 2019 - annualreviews.org
Astrocytes are morphologically complex, ubiquitous cells that are viewed as a
homogeneous population tiling the entire central nervous system (CNS). However, this view …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

The biology of regeneration failure and success after spinal cord injury

AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Astrocyte-immune cell interactions in physiology and pathology

RT Han, RD Kim, AV Molofsky, SA Liddelow - Immunity, 2021 - cell.com
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …