Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Pandemics throughout history

J Piret, G Boivin - Frontiers in microbiology, 2021 - frontiersin.org
The emergence and spread of infectious diseases with pandemic potential occurred
regularly throughout history. Major pandemics and epidemics such as plague, cholera, flu …

Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Humoral and cellular immunity to SARS-CoV-2 vaccination in renal transplant versus dialysis patients: a prospective, multicenter observational study using mRNA …

J Stumpf, T Siepmann, T Lindner, C Karger… - The Lancet Regional …, 2021 - thelancet.com
Background Dialysis and kidney transplant patients are vulnerable populations for COVID-
19 related disease and mortality. Methods We conducted a prospective study exploring the …

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

K Bok, S Sitar, BS Graham, JR Mascola - Immunity, 2021 - cell.com
The development of effective vaccines to combat infectious diseases is a complex multi-year
and multi-stakeholder process. To accelerate the development of vaccines for coronavirus …

Challenges of storage and stability of mRNA-based COVID-19 vaccines

MN Uddin, MA Roni - Vaccines, 2021 - mdpi.com
In December 2019, a new and highly pathogenic coronavirus emerged—coronavirus
disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome …

Self-assembled mRNA vaccines

J Kim, Y Eygeris, M Gupta, G Sahay - Advanced drug delivery reviews, 2021 - Elsevier
Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …

[HTML][HTML] Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions

AI Abulsoud, HM El-Husseiny, AA El-Husseiny… - Biomedicine & …, 2023 - Elsevier
COVID-19 is a worldwide pandemic caused by SARS-coronavirus-2 (SARS-CoV-2). Less
than a year after the emergence of the Covid-19 pandemic, many vaccines have arrived on …

SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review

H Fathizadeh, S Afshar, MR Masoudi… - International Journal of …, 2021 - Elsevier
The world has been suffering from COVID-19 disease for more than a year, and it still has a
high mortality rate. In addition to the need to minimize transmission of the virus through non …

New-age vaccine adjuvants, their development, and future perspective

SK Verma, P Mahajan, NK Singh, A Gupta… - Frontiers in …, 2023 - frontiersin.org
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …