Mitochondria as playmakers of apoptosis, autophagy and senescence
Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …
species. They are responsible for managing cell life and death by a balanced homeostasis …
Sirtuins, cell senescence, and vascular aging
Y Kida, MS Goligorsky - Canadian Journal of Cardiology, 2016 - Elsevier
The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …
dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT …
Small molecule compounds that induce cellular senescence
To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …
These cellular senescence states may differ substantially from each other, as well as from …
Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy
T Mustoe - The American Journal of Surgery, 2004 - Elsevier
The development of new therapies for treatment of chronic wounds has not matched the
availability of treatment modalities forecast by the pharmaceutical industry. This is …
availability of treatment modalities forecast by the pharmaceutical industry. This is …
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation
Z Zhen, Y Chen, H Wang, H Tang, H Zhang… - Nature …, 2023 - nature.com
Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …
detects DNA fragments to trigger an innate immune response. Recently, accumulating …
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian
Sirt1 NAD+-dependent protein deacetylase, the closest homolog of Sir2, regulates cell cycle …
Sirt1 NAD+-dependent protein deacetylase, the closest homolog of Sir2, regulates cell cycle …
Human cell senescence as a DNA damage response
T Von Zglinicki, G Saretzki, J Ladhoff… - Mechanisms of ageing …, 2005 - Elsevier
It has been established that telomere-dependent replicative senescence of human
fibroblasts is stress-dependent. First, it was shown that telomere shortening, which is a major …
fibroblasts is stress-dependent. First, it was shown that telomere shortening, which is a major …
When cells get stressed: an integrative view of cellular senescence
I Ben-Porath, RA Weinberg - The Journal of clinical …, 2004 - Am Soc Clin Investig
Cells entering a state of senescence undergo a permanent cell cycle arrest, accompanied
by a set of functional and morphological changes. Senescence of cells occurs following an …
by a set of functional and morphological changes. Senescence of cells occurs following an …
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
Abstract The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling
modules are frequently mutated in sporadic human cancer. Although each of these …
modules are frequently mutated in sporadic human cancer. Although each of these …
Senescence, apoptosis or autophagy? When a damaged cell must decide its path–a mini-review
Many features of aging result from the incapacity of cells to adapt to stress conditions. When
damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two …
damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two …