Development of atomoxetine-loaded NLC in situ gel for nose-to-brain delivery: optimization, in vitro, and preclinical evaluation
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro …
The strategies to avoid blood brain barrier are been explored to improve brain targeting
therapeutics in order to ensure potential prospects of nose to brain delivery. In this research …
therapeutics in order to ensure potential prospects of nose to brain delivery. In this research …
[PDF][PDF] Drug delivery to the brain–lipid nanoparticles-based approach
V Gugleva, V Andonova - Pharmacia, 2023 - pharmacia.pensoft.net
The complex structure of the human brain defines it as one of the most inaccessible organs
in terms of drug delivery. The blood-brain barrier (BBB) represents a microvascular network …
in terms of drug delivery. The blood-brain barrier (BBB) represents a microvascular network …
Intranasal delivery of chitosan decorated nanostructured lipid carriers of Buspirone for brain targeting: Formulation development, optimization and In-Vivo preclinical …
KM Noorulla, M Yasir, F Muzaffar, S Roshan… - Journal of Drug Delivery …, 2022 - Elsevier
The current research was portrayed to design and optimize the Chitosan (CH) coated
Buspirone-loaded nanostructured lipid carriers (BPE-CH-NLCs) for nose to brain delivery …
Buspirone-loaded nanostructured lipid carriers (BPE-CH-NLCs) for nose to brain delivery …
Development of Nanomedicines for the Treatment of Alzheimer's Disease: Raison d'être, Strategies, Challenges and Regulatory Aspects
F Mazahir, MI Alam, AK Yadav - Ageing Research Reviews, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by
progressive loss of memory. Presently, AD is challenging to treat with current drug therapy …
progressive loss of memory. Presently, AD is challenging to treat with current drug therapy …
Formulation and optimization of butenafine-loaded topical nano lipid carrier-based gel: characterization, irritation study, and anti-fungal activity
The present study aims to prepare and optimize butenafine hydrochloride NLCs formulation
using solid and liquid lipid. The optimized selected BF-NLCopt was further converted into …
using solid and liquid lipid. The optimized selected BF-NLCopt was further converted into …
Chitosan-ethyl cellulose microspheres of domperidone for nasal delivery: Preparation, in-vitro characterization, in-vivo study for pharmacokinetic evaluation and …
The strategies to avoid the first-pass metabolism via nose to systemic pathway are been
explored to improve the bioavailability of the therapeutic agents. The present study aimed to …
explored to improve the bioavailability of the therapeutic agents. The present study aimed to …
Formulation of carteolol chitosomes for ocular delivery: formulation optimization, ex-vivo permeation, and ocular toxicity examination
A Zafar, NK Alruwaili, SS Imam… - Cutaneous and …, 2021 - Taylor & Francis
Background: Conventional delivery systems like solution and suspension are commonly
used for the treatment of ocular diseases but have low corneal residence time and hence the …
used for the treatment of ocular diseases but have low corneal residence time and hence the …
Formulation of Chitosan-Coated Piperine NLCs: Optimization, In Vitro Characterization, and In Vivo Preclinical Assessment
A Zafar, NK Alruwaili, SS Imam, OA Alsaidan… - AAPS …, 2021 - Springer
In the present research work, surface-modified nanostructured lipid carriers (NLCs) with
chitosan (CH) were prepared to improve the therapeutic efficacy of piperine (PP). NLCs …
chitosan (CH) were prepared to improve the therapeutic efficacy of piperine (PP). NLCs …
Rizatriptan loaded bilosomes for nose to brain delivery: Fabrication, statistical optimization, and biological evaluation
NK Alruwaili, OA Alsaidan, A Zafar, HH Alhassan… - Journal of Drug Delivery …, 2025 - Elsevier
Rizatriptan (RTP) is an anti-migraine drug and after oral administration, it exhibits low
bioavailability (45%) due to high first-pass hepatic metabolism. Therefore, to resolve this …
bioavailability (45%) due to high first-pass hepatic metabolism. Therefore, to resolve this …