Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as
a critical regulator of many physiological and pathophysiological processes, including …

Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …

Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression
via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor …

The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

Simple Summary Sphingolipids are membrane-associated lipids that are involved in signal
transduction pathways regulating cell death, growth, and migration. In cancer cells …

Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

Ceramide, a bioactive sphingolipid, is now at the forefront of cancer research. Classically,
ceramide is thought to induce death, growth inhibition, and senescence in cancer cells …