[HTML][HTML] Ferroptosis: A novel therapeutic target of natural products against doxorubicin-induced cardiotoxicity

X Yi, Q Wang, M Zhang, Q Shu, J Zhu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Doxorubicin (DOX), a commonly used chemotherapy drug, is hindered due to its tendency to
induce cardiotoxicity (DIC). Ferroptosis, a novel mode of programmed cell death, has …

FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM

Y Bi, H Xu, X Wang, H Zhu, J Ge, J Ren, Y Zhang - Cell death & disease, 2022 - nature.com
Doxorubicin (DOX) is an effective anthracycline chemotherapeutic anticancer drug with its
life-threatening cardiotoxicity severely limiting its clinical application. Mitochondrial damage …

[HTML][HTML] Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers

I Moscoso, M Rodríguez-Mañero… - International Journal of …, 2024 - mdpi.com
Cardiotoxicity (CDTX) is a critical side effect of many cancer therapies, leading to increased
morbidity and mortality if not addressed. Early detection of CDTX is essential, and while …

New insights in the era of clinical biomarkers as potential predictors of systemic therapy-induced cardiotoxicity in women with breast cancer: a systematic review

A Alexandraki, E Papageorgiou, M Zacharia… - Cancers, 2023 - mdpi.com
Simple Summary Cancer therapy-related cardiac dysfunction (CTRCD) has been an urgent
medical issue in patients that receive breast cancer therapies including anthracycline-based …

[HTML][HTML] Early detection of anthracycline-induced cardiotoxicity

W Feng, Q Wang, Y Tan, J Qiao, Q Liu, B Yang… - Clinica Chimica …, 2024 - Elsevier
Although anthracyclines are important anticancer agents, their use is limited due to various
adverse effects, particularly cardiac toxicity. Mechanisms underlying anthracycline-induced …

MicroRNA delivery based on nanoparticles of cardiovascular diseases

N Wang, C Chen, J Ren, D Dai - Molecular and Cellular Biochemistry, 2024 - Springer
Cardiovascular disease, especially myocardial infarction, is a serious threat to human
health. Many drugs currently used cannot achieve the desired therapeutic effect due to the …

Non-coding RNAs as regulators of the Hippo pathway in cardiac development and cardiovascular disease

M Song, H Wang, C Liu, S Jin, B Liu… - Frontiers in …, 2024 - frontiersin.org
Cardiovascular diseases pose a serious threat to human health. The onset of cardiovascular
diseases involves the comprehensive effects of multiple genes and environmental factors …

Circulating MicroRNA as Biomarkers of Anthracycline-Induced Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review

HM Boen, M Cherubin, C Franssen, AB Gevaert… - Cardio Oncology, 2024 - jacc.org
Close monitoring for cardiotoxicity during anthracycline chemotherapy is crucial for early
diagnosis and therapy guidance. Currently, monitoring relies on cardiac imaging and serial …

Modeling Cardiotoxicity in Pediatric Oncology Patients Using Patient-Specific iPSC-Derived Cardiomyocytes Reveals Downregulation of Cardioprotective microRNAs

I Reinal, I Ontoria-Oviedo, M Selva, M Casini… - Antioxidants, 2023 - mdpi.com
Anthracyclines are widely used in the treatment of many solid cancers, but their efficacy is
limited by cardiotoxicity. As the number of pediatric cancer survivors continues to rise, there …

miR-4732-3p prevents lung cancer progression via inhibition of the TBX15/TNFSF11 axis

P Li, Y Li, S Bai, Y Zhang, L Zhao - Epigenomics, 2023 - Taylor & Francis
Aim: Possible roles of miRNAs in cancer treatment have been highly studied. This study
aimed to elucidate the role of miR-4732-3p in lung cancer. Methods: Bioinformatics analysis …