Abstract Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine
kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways. S1P …

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Human pandemic H1N1 2009 influenza virus rapidly infected millions worldwide and was
associated with significant mortality. Antiviral drugs that inhibit influenza virus replication are …

Organ fibrosis is a pathological condition associated with chronic inflammatory diseases. In
fibrosis, excessive deposition of extracellular matrix (ECM) severely impairs tissue …

The fibrotic process could be easily defined as a pathological excess of extracellular matrix
deposition, leading to disruption of tissue architecture and eventually loss of function; …

Sphingolipids are components of all eukaryotic cells that play important roles in a wide
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …

The bioactive sphingolipids ceramide, sphingosine and sphingosine‐1‐phosphate (S1P)
are important signalling molecules that regulate a diverse array of cellular processes. Most …

Abstract Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin
by the sequential enzymatic actions of sphingomyelinase, ceramidase, and sphingosine …

Aims Activation of cardiac fibroblasts and their differentiation into myofibroblasts is a key
event in the progression of cardiac fibrosis that leads to end-stage heart failure. Apelin, an …