Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

Background Meningococcal serogroup B disease disproportionately affects infants. We
assessed lot-to-lot consistency, safety and immunogenicity, and the effect of concomitant …

A unique multicomponent vaccine against serogroup B meningococci incorporates the novel
genome-derived proteins fHbp, NHBA, and NadA that may vary in sequence and level of …

Clin Microbiol Infect 2012; 18 (Suppl. 5): 109–116 Abstract Vaccines have a significant
impact on public health, and vaccinology in the era of genomics is taking advantage of new …

The utility of wild-type outer membrane vesicle (wtOMV) vaccines against serogroup B
(MenB) meningococcal disease has been explored since the 1970s. Public health …

Background. In the absence of an efficacious broadly protective vaccine, serogroup B
Neisseria meningitidis (MenB) is the leading cause of bacterial meningitis and septicemia in …

Adjuvants increase vaccine potency largely by activating innate immunity and promoting
inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use …

No broadly effective vaccines are available for prevention of group B meningococcal
disease, which accounts for> 50% of all cases. The group B capsule is an autoantigen and …

GNA2132 is a Neisseria meningitidis antigen of unknown function, discovered by reverse
vaccinology, which has been shown to induce bactericidal antibodies in animal models …