Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

Traditional chemotherapy is being considered due to hindrances caused by systemic
toxicity. Currently, the administration of multiple chemotherapeutic drugs with different …

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Lactylation is a lactate-induced post-translational modification best known for its roles in
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …

Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …

Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

Genomic and mitochondrial DNA molecules are exposed continuously for a damaging
activity of chemical, physical, and internal genotoxicants. When DNA repair machinery is not …

The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …