COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …

With advancements in biomarkers and momentum in precision medicine, biomarker‐guided
trials such as basket trials and umbrella trials have been developed under the master …

Platform trials are a type of randomized clinical trial that allow simultaneous comparison of
multiple intervention groups against a single control group that serves as a common control …

Purpose Recent years have seen a change in the way that clinical trials are being
conducted. There has been a rise of designs more flexible than traditional adaptive and …

Objectives The objective of the study was to outline key considerations for general clinical
readers when critically evaluating publications on platform trials and for researchers when …

Motivation Platform designs-master protocols that allow for new treatment arms to be added
over time-have gained considerable attention in recent years. Between 2001 and 2019, 16 …

Importance Platform trial design allows the introduction of new interventions after the trial is
initiated and offers efficiencies to clinical research. However, limited guidance exists on the …

This paper shows the scale of global health research and the context in which we frame the
subsequent papers in the Series. In this Series paper, we provide a historical perspective on …

Background Basket trials are increasingly used in oncology drug development for early
signal detection, accelerated tumor-agnostic approvals, and prioritization of promising tumor …

Background The efficiencies that master protocol designs can bring to modern drug
development have seen their increased utilization in oncology. Growing interest has also …