Periphery and brain, innate and adaptive immunity in Parkinson's disease

AS Harms, SA Ferreira, M Romero-Ramos - Acta neuropathologica, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

[HTML][HTML] Machine learning in healthcare

H Habehh, S Gohel - Current genomics, 2021 - ncbi.nlm.nih.gov
Abstract Recent advancements in Artificial Intelligence (AI) and Machine Learning (ML)
technology have brought on substantial strides in predicting and identifying health …

Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

ML Choi, A Chappard, BP Singh, C Maclachlan… - Nature …, 2022 - nature.com
Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

Mitochondrial dysfunction, protein misfolding and neuroinflammation in Parkinson's disease: roads to biomarker discovery

A Picca, F Guerra, R Calvani, R Romano… - Biomolecules, 2021 - mdpi.com
Parkinson's Disease (PD) is a highly prevalent neurodegenerative disease among older
adults. PD neuropathology is marked by the progressive loss of the dopaminergic neurons …

[HTML][HTML] Immune responses in the Parkinson's disease brain

F Weiss, A Labrador-Garrido, N Dzamko… - Neurobiology of …, 2022 - Elsevier
Immune changes occur in all neurodegenerative conditions, but there are significant
differences between diseases. For Parkinson's disease (PD), the immune system …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

A Comprehensive review on AI-enabled models for Parkinson's disease diagnosis

S Dixit, K Bohre, Y Singh, Y Himeur, W Mansoor… - Electronics, 2023 - mdpi.com
Parkinson's disease (PD) is a devastating neurological disease that cannot be identified with
traditional plasma experiments, necessitating the development of a faster, less expensive …

Differential gut microbiota and intestinal permeability between frail and healthy older adults: A systematic review

NH Rashidah, SM Lim, CF Neoh, ABA Majeed… - Ageing research …, 2022 - Elsevier
This systematic review appraised previous findings on differential gut microbiota
composition and intestinal permeability markers between frail and healthy older adults. A …

Mitochondrial signatures in circulating extracellular vesicles of older adults with Parkinson's disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) …

A Picca, F Guerra, R Calvani, F Marini… - Journal of clinical …, 2020 - mdpi.com
Systemic inflammation and mitochondrial dysfunction are involved in neurodegeneration in
Parkinson's disease (PD). Extracellular vesicle (EV) trafficking may link inflammation and …

Machine learning and artificial intelligence in the service of medicine: Necessity or potentiality?

T Alsuliman, D Humaidan, L Sliman - Current research in translational …, 2020 - Elsevier
Motivation As a result of the worldwide health care system digitalization trend, the produced
healthcare data is estimated to reach as much as 2314 Exabytes of new data generated in …