The germinal centre B cell response to SARS-CoV-2
BJ Laidlaw, AH Ellebedy - Nature Reviews Immunology, 2022 - nature.com
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
COVID-19 and autoimmune diseases
Y Liu, AH Sawalha, Q Lu - Current opinion in rheumatology, 2021 - journals.lww.com
We present a review of the association between COVID-19 and autoimmune diseases,
focusing on similarities in immune responses, cross-reactivity of SARS-CoV-2, the …
focusing on similarities in immune responses, cross-reactivity of SARS-CoV-2, the …
[HTML][HTML] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19
S Notarbartolo, V Ranzani, A Bandera, P Gruarin… - Science …, 2021 - science.org
To understand how a protective immune response against SARS-CoV-2 develops over time,
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
we integrated phenotypic, transcriptional, and repertoire analyses on PBMCs from patients …
Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity?
Many nations are pursuing the rollout of SARS-CoV-2 vaccines as an exit strategy from
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …
unprecedented COVID-19-related restrictions. However, the success of this strategy relies …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
B cell subsets as severity-associated signatures in COVID-19 patients
VA Sosa-Hernandez, J Torres-Ruiz… - Frontiers in …, 2020 - frontiersin.org
Background SARS-CoV-2 infection represents a global health problem that has affected
millions of people. The fine host immune response and its association with the disease …
millions of people. The fine host immune response and its association with the disease …
Durable SARS-CoV-2 B cell immunity after mild or severe disease
Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2–
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …