The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

In this report, we show that hyperglycemia-induced overproduction of superoxide by the
mitochondrial electron transport chain activates the three major pathways of hyperglycemic …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

Poly (ADP-ribose) polymerase-1 (PARP-1a) has been an actively pursued drug discovery
target for almost 3 decades. Often referred to as the “guardian angel of DNA”, 1 this …

Quorum sensing (QS) is cell communication that is widely used by bacterial pathogens to
coordinate the expression of several collective traits, including the production of multiple …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …