Traditionally, we have considered genetic mutations that cause neurodevelopmental
diseases to be inherited or de novo germline mutations. Recently, we have come to …

Neurofibromatosis type II (NF2) is a tumor predisposition syndrome characterized by the
development of distinctive nervous system lesions. NF2 results from loss-of-function …

Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …

Abstract Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder
characterized by the development of multiple nervous system tumors due to mutation in the …

Objective Because clinically validated biomarkers for neurofibromatosis 1 (NF1) and
neurofibromatosis 2 (NF2) have not been identified, we aimed to determine whether …

Highlights•WHO grading of meningioma may not reflect tumor biology.•Molecular
characterization of meningioma may more closely correlate to tumor biology.•Genetic …

Ependymomas encompass multiple clinically relevant tumor types based on localization and
molecular profiles. Tumors of the methylation class “spinal ependymoma”(SP-EPN) …

Genetic testing and management of individuals at risk for NF2‐related schwannomatosis is
complicated by the high rate of mosaicism resulting in a milder, later onset, more …

Vestibular schwannomas (VSs) are benign tumors composed of differentiated neoplastic
Schwann cells. They can be classified into two groups: sporadic VS and those associated …

While the neural crest cell population gives rise to an extraordinary array of derivatives,
including elements of the craniofacial skeleton, skin pigmentation, and peripheral nervous …