High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

Sustained imbalance in intracellular calcium (Ca2+) entry and clearance alters cellular
integrity, ultimately leading to cellular homeostasis disequilibrium and cell death …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …

In this study, pharmacophore based 3D QSAR models for human acetylcholinesterase
(AChE) inhibitors were generated, with good significance, statistical values (r2training …

It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and
energy supply. Their unique morphological and functional features have recently brough …

The prevalence of depression has dramatically increased, and it has been estimated that
over 300 million people suffer from depression all over the world. Depression is highly …

Alzheimer disease (AD) is characterized by neurodegeneration marked by loss of synapses
and spines associated with hyperphosphorylation of tau protein. Accumulating amyloid β …

Progressive decrease in neuronal function is an established feature of Alzheimer's disease
(AD). Previous studies have shown that amyloid β (Aβ) peptide induces acute increase in …

Emerging evidence indicates that amyloid β peptide (Aβ) initially induces subtle alterations
in synaptic function in Alzheimer disease. We have recently shown that Aβ binds to β 2 …

Alteration of ryanodine receptor (RyR)-mediated calcium (Ca 2+) signaling has been
reported in Alzheimer disease (AD) models. However, the molecular mechanisms …