Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: a review of the current literature

MD Trietsch, LS Nooij, KN Gaarenstroom… - Gynecologic …, 2015 - Elsevier
Vulvar cancer is a relatively rare gynecologic malignancy with an annual incidence in
developed countries of approximately 2 per 100,000 women. Vulvar squamous cell …

Surgery and radiotherapy in vulvar cancer

JA De Hullu, AGJ Van der Zee - Critical reviews in oncology/hematology, 2006 - Elsevier
The majority of patients with vulvar cancer have squamous cell carcinomas (SCC). The
cornerstone of the treatment is surgery. Radical vulvectomy with “en bloc” inguinofemoral …

[HTML][HTML] Vulvar cancer subclassification by HPV and p53 status results in three clinically distinct subtypes

KE Kortekaas, E Bastiaannet, HC van Doorn… - Gynecologic …, 2020 - Elsevier
Objective There is great need for better risk stratification in vulvar squamous cell carcinoma
(VSCC). Our aim was to define the prognostic significance of stratifying VSCC based on p16 …

Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer

A Gadducci, L Cionini, A Romanini, A Fanucchi… - Critical reviews in …, 2006 - Elsevier
During the last decades there has been a continuing evolution in the surgical approach of
squamous cell carcinoma of the vulva that has been traditionally treated with radical …

[HTML][HTML] Tumour-free margins in vulvar squamous cell carcinoma: Does distance really matter?

LS Nooij, MA Van der Slot, OM Dekkers… - European journal of …, 2016 - Elsevier
Background There is no consensus on the width of tumour-free margins after surgery for
vulvar squamous cell carcinoma (VSCC). Most current guidelines recommend tumour-free …

[HTML][HTML] Risk factors and treatment for recurrent vulvar squamous cell carcinoma

LS Nooij, FAM Brand, KN Gaarenstroom… - Critical reviews in …, 2016 - Elsevier
Abstract Recurrent disease occurs in 12–37% of patients with vulvar squamous cell
carcinoma (VSCC). Decisions about treatment of recurrent VSCC mainly depend on the …

Vulvar squamous cell carcinoma (VSCC) as two diseases: HPV status identifies distinct mutational profiles including oncogenic fibroblast growth factor receptor 3

JI Weberpals, B Lo, MM Duciaume, JN Spaans… - Clinical Cancer …, 2017 - AACR
Purpose: Patients with advanced or recurrent invasive vulvar squamous cell carcinoma
(VSCC) have limited treatment options and a grave prognosis. Understanding the genomic …

Diagnosis, therapy and follow-up care of vulvar cancer and its precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November …

HG Schnürch, S Ackermann, CD Alt… - Geburtshilfe und …, 2016 - thieme-connect.com
Purpose: This is an official guideline, published and coordinated by the Arbeitsgemeinschaft
Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of the Deutsche …

Vulvar cancer is not a disease of the elderly: Treatment and outcome at a tertiary referral centre in South Africa

JL Butt, MH Botha - South African Medical Journal, 2017 - ajol.info
Background. An increase in vulvar cancer in young women is attributed to infection with
oncogenic human papillomavirus (HPV). South Africa (SA) has a high prevalence of HPV …

[PDF][PDF] Whole-body [18F] fluoro-2-deoxyglucose positron emission tomography scan as combined PET-CT staging prior to planned radical vulvectomy and …

MW Kamran, F O'Toole, K Meghen… - Eur. J. Gynaec. Oncol …, 2014 - researchgate.net
Surgery is the mainstay of treatment for vulvar cancer. FIGO staging requires
histopathological detail of the primary tumor and inguinofemoral lymph nodes but groin …