Viral pathogens must overcome innate antiviral responses to replicate successfully in the
host organism. Some of the mechanisms viruses use to interfere with antiviral responses in …

The mammalian reoviruses and rotaviruses have evolved specific mechanisms to evade the
Type I interferon (IFN) antiviral response. Rotavirus likely represses the IFN response by at …

Rotavirus nonstructural protein NSP1 can inhibit expression of interferon (IFN) and IFN-
stimulated gene products by inducing proteasome-mediated degradation of IFN-regulatory …

Interferon regulatory factor 3 (IRF3) is a key transcription factor involved in the induction of
interferon (IFN) in response to viral infection. Rotavirus non-structural protein NSP1 binds to …

Rotavirus (RV) replicates efficiently in intestinal epithelial cells (IECs) in vivo despite the
activation of a local host interferon (IFN) response. Previously, we demonstrated that …

Rotaviruses (RVs) are the leading cause of severe gastroenteritis in young children,
accounting for half a million deaths annually worldwide. RV encodes non-structural protein 1 …

Rotavirus host range restriction forms a basis for strain attenuation although the underlying
mechanisms are unclear. In mouse fibroblasts, the inability of rotavirus NSP1 to mediate …

The rotavirus nonstructural protein NSP1 acts as an antagonist of the host antiviral response
by inducing degradation of key proteins required to activate interferon (IFN) production …

Rotavirus is a primary cause of severe dehydrating gastroenteritis in infants and young
children. The virus is sensitive to the antiviral effects triggered by the interferon (IFN) …

Group A rotaviruses infect and cause diarrhea in the young of a broad range of terrestrial
mammals, but it is unknown, to our knowledge, whether they infect marine mammals. During …