Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the
pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to …

BACKGROUND: The goals of asthma treatment include preventing recurrent exacerbations.
Yet there is no consensus about the terminology for describing or defining “exacerbation” or …

Background Severe refractory asthma is a heterogeneous disease. We sought to determine
statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to …

Rationale Recent observations, especially in adults, suggest that asthma severity may be
associated with fungal sensitization. Other studies suggest that some patients with severe …

Background The importance and specific role (s) of eosinophils in modulating the
immune/inflammatory phenotype of allergic pulmonary disease remain to be defined …

Introduction Asthma is driven by an inflammatory response against normally harmless
environmental inorganic and organic compounds in the respiratory tract. Immune responses …

Rationale: The release of eosinophil granule proteins in the lungs of patients with asthma
has been dogmatically linked with lung remodeling and airway hyperresponsiveness …

Asthma has a high prevalence worldwide, and contributes significantly to the socioeconomic
burden. According to a classical paradigm, asthma symptoms are attributable to an allergic …

Abstract Background and Objectives: Historically, obstructive airway diseases such as
asthma and COPD are classified as different diseases. Although the definitions are clearly …

The use of the long-acting anticholinergic agent, tiotropium, as maintenance of therapy in
asthma, has been shown to be effective in some patients with moderate to severe asthma …