Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The
pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T …

T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the
naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial …

Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the
control of self tolerance and inflammatory responses. Recent studies have revealed a …

The immune system has evolved to mount an effective defense against pathogens and to
minimize deleterious immune-mediated inflammation caused by commensal …

Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as
well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

The nuclear factor‐κB (NF‐κB) family of transcription factors plays important roles in various
biological processes including apoptosis, stress response, immunity, and inflammation. NF …

Natural killer T cells (NKT cells) are CD1d-restricted, lipid antigen–reactive,
immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and …

Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive
immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of …