Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …

Highlights•Hsp90 is a molecular chaperone that modulates the function of many client
proteins.•Morphogenesis is an important Candida albicans virulence trait.•Hsp90 regulates …

Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

The evolution of drug resistance in microbial pathogens provides a paradigm for
investigating evolutionary dynamics with important consequences for human health …

Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …

Fungal diseases are severe and have very high morbidity as well as up to 60% mortality for
patients diagnosed with invasive fungal infection. In this review, in vitro and in vivo studies …

Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …

Candida albicans is a major fungal pathogen of humans. This yeast is carried by many
individuals as a harmless commensal, but when immune defences are perturbed it causes …

Transcriptional regulation of ergosterol biosynthesis in fungi is crucial for sterol homeostasis
and for resistance to azole drugs. In Saccharomyces cerevisiae, the Upc2 transcription factor …