The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

A proper balance between chemical reduction and oxidation (known as redox balance) is
essential for normal cellular physiology. Deregulation in the production of oxidative species …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

Background Mutations in LRRK2 are a common genetic cause of Parkinson's disease (PD).
LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a …

The formation of a neurite, the basis for axons and dendrites, begins with the concerted
accumulation and organization of actin and microtubules. Whereas much is known about the …

The generation of abnormally high levels of reactive oxygen species (ROS) is linked to
cellular dysfunction, including neuronal toxicity and neurodegeneration. However …

Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological
changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily …

Many aspects of membrane-trafficking events are regulated by Rab-family small GTPases.
Neurite outgrowth requires massive addition of proteins and lipids to the tips of growing …

Rab GTPases are key regulators of eukaryotic membrane traffic, and their functions and
activities are limited to particular intracellular transport steps and their membrane …