Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …

In this review, we describe the application of experimental data and modeling of intracellular
endocytic trafficking mechanisms with a focus on the process of clathrin-mediated …

In eukaryotic cells, the internalization of extracellular cargo via the endocytic machinery is an
important regulatory process required for many essential cellular functions. The role of …

Curvature-sensing and curvature-remodeling proteins, such as Amphiphysin, Epsin, and
Exo70, are known to reshape cell membranes, and this remodeling event is essential for key …

In intracellular trafficking, a definitive understanding of the interplay between protein binding
and membrane morphology remains incomplete. The authors describe a computational …

The membrane-surface migration of curvature-inducing proteins in response to membrane
curvature gradients has been investigated using Monte Carlo simulations of a curvilinear …

We present a computational methodology for incorporating thermal effects and calculating
relative free energies for elastic fluid membranes subject to spatially dependent intrinsic …

Caveolae-mediated vesiculation refers to the∼ 100 nm cave-like plasma membrane
invaginations, which function as macromolecular transport vesicles that regulate cellular …

Over the past fifty years, molecular mechanics (MM) has become firmly established as an
important tool in the study of biomolecular systems. It has revolutionized the understanding …

An intriguing question in cell biology is “how do cells regulate their shape?” It is commonly
believed that the observed cellular morphologies are a result of the complex interaction …