Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering
The technologies related to ex vivo models and lab-on-a-chip devices for studying the
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …
regeneration of brain, spinal cord, and peripheral nerve tissues are essential tools for neural …
Mechanism of neuroprotection against experimental spinal cord injury by riluzole or methylprednisolone
C Sámano, A Nistri - Neurochemical research, 2019 - Springer
Any spinal cord injury carries the potential for persistent disability affecting motor, sensory
and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of …
and autonomic functions. To prevent this outcome, it is highly desirable to block a chain of …
Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos)
A Kuzhandaivel, A Nistri, M Mladinic - Cellular and molecular neurobiology, 2010 - Springer
Kainate is an effective excitotoxic agent to lesion spinal cord networks, thus providing an
interesting model for investigating basic mechanisms of spinal cord injury. The present study …
interesting model for investigating basic mechanisms of spinal cord injury. The present study …
Molecular Mechanisms Underlying Cell Death in Spinal Networks in Relation to Locomotor Activity After Acute Injury in vitro
A Kuzhandaivel, A Nistri, GL Mazzone… - Frontiers in cellular …, 2011 - frontiersin.org
Understanding the pathophysiological changes triggered by an acute spinal cord injury is a
primary goal to prevent and treat chronic disability with a mechanism-based approach. After …
primary goal to prevent and treat chronic disability with a mechanism-based approach. After …
GABAergic mechanisms can redress the tilted balance between excitation and inhibition in damaged spinal networks
GL Mazzone, A Mohammadshirazi, JB Aquino… - Molecular …, 2021 - Springer
Correct operation of neuronal networks depends on the interplay between synaptic
excitation and inhibition processes leading to a dynamic state termed balanced network. In …
excitation and inhibition processes leading to a dynamic state termed balanced network. In …
Riluzole: what it does to spinal and brainstem neurons and how it does it
A Cifra, GL Mazzone, A Nistri - The Neuroscientist, 2013 - journals.sagepub.com
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative
disorder for which the only licensed treatment is riluzole. Although riluzole clinical efficacy is …
disorder for which the only licensed treatment is riluzole. Although riluzole clinical efficacy is …
Modeling traumatic injury in organotypic spinal cord slice culture obtained from adult rat
Nowadays there are various models of spinal cord injury (SCI) that recreate mechanisms of
human SCI. The ex vivo modeling of injury is a robust approach, confronts with less …
human SCI. The ex vivo modeling of injury is a robust approach, confronts with less …
Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord
GL Mazzone, G Margaryan, A Kuzhandaivel… - Neuroscience, 2010 - Elsevier
While excitotoxicity is a major contributor to the pathophysiology of acute spinal injury, its
time course and the extent of cell damage in relation to locomotor network activity remain …
time course and the extent of cell damage in relation to locomotor network activity remain …
ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury
GL Mazzone, P Veeraraghavan… - Neuroscience, 2017 - Elsevier
In the spinal cord high extracellular glutamate evokes excitotoxic damage with neuronal loss
and severe locomotor impairment. During the cell dysfunction process, extracellular pH …
and severe locomotor impairment. During the cell dysfunction process, extracellular pH …
Postnatal developmental profile of neurons and glia in motor nuclei of the brainstem and spinal cord, and its comparison with organotypic slice cultures
A Cifra, GL Mazzone, F Nani, A Nistri… - Developmental …, 2012 - Wiley Online Library
In vitro preparations of the neonatal rat spinal cord or brainstem are useful to investigate the
organization of motor networks and their dysfunction in neurological disease models. Long …
organization of motor networks and their dysfunction in neurological disease models. Long …