Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

α-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and
released into the circulation. Chronic kidney disease (CKD) is a state of α-Klotho deficiency …

Abstract αKlotho is a multifunctional protein highly expressed in the kidney. Soluble αKlotho
is released through cleavage of the extracellular domain from membrane αKlotho by …

The klotho gene encodes a type I single-pass transmembrane protein that contains a large
extracellular domain, a membrane spanning segment, and a short intracellular domain …

Over the past decade, science has greatly advanced our understanding of interdependent
feedback mechanisms involving the heart, lung, and kidney. Organ injury is the …

Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …

Cardiac inflammation and oxidative stress play a key role in the pathogenesis of diabetic
cardiomyopathy (DCM). The anti-aging protein Klotho has been found to protect cells from …

Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and
diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …