The dual nature of the nucleolus
The nucleolus is best known for housing the highly ordered assembly line that produces
ribosomal subunits. The> 100 ribosome assembly factors in the nucleolus are thought to …
ribosomal subunits. The> 100 ribosome assembly factors in the nucleolus are thought to …
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases
MA Mensah, H Niskanen, AP Magalhaes, S Basu… - Nature, 2023 - nature.com
Thousands of genetic variants in protein-coding genes have been linked to disease.
However, the functional impact of most variants is unknown as they occur within intrinsically …
However, the functional impact of most variants is unknown as they occur within intrinsically …
PTEN proteoforms in biology and disease
Proteoforms are specific molecular forms of protein products arising from a single gene that
possess different structures and different functions. Therefore, a single gene can produce a …
possess different structures and different functions. Therefore, a single gene can produce a …
SLERT regulates DDX21 rings associated with Pol I transcription
Dysregulated rRNA synthesis by RNA polymerase I (Pol I) is associated with uncontrolled
cell proliferation. Here, we report a box H/ACA small nucleolar RNA (snoRNA)-ended long …
cell proliferation. Here, we report a box H/ACA small nucleolar RNA (snoRNA)-ended long …
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
D Dilworth, RP Hanley, R Ferreira de Freitas… - Nature chemical …, 2022 - nature.com
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
A downy mildew effector attenuates salicylic acid–triggered immunity in Arabidopsis by interacting with the host mediator complex
MC Caillaud, S Asai, G Rallapalli, S Piquerez… - PLoS …, 2013 - journals.plos.org
Plants are continually exposed to pathogen attack but usually remain healthy because they
can activate defences upon perception of microbes. However, pathogens have evolved to …
can activate defences upon perception of microbes. However, pathogens have evolved to …
Galaxy tools and workflows for sequence analysis with applications in molecular plant pathology
The Galaxy Project offers the popular web browser-based platform Galaxy for running
bioinformatics tools and constructing simple workflows. Here, we present a broad collection …
bioinformatics tools and constructing simple workflows. Here, we present a broad collection …
Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription
X Huang, M He, S Huang, R Lin, M Zhan, D Yang… - Molecular Cancer, 2019 - Springer
Background CircRNAs are found to affect initiation and progression of several cancer types.
However, whether circRNAs are implicated in gallbladder cancer (GBC) progression …
However, whether circRNAs are implicated in gallbladder cancer (GBC) progression …
Principles of protein targeting to the nucleolus
RM Martin, G Ter-Avetisyan, HD Herce, AK Ludwig… - Nucleus, 2015 - Taylor & Francis
The nucleolus is the hallmark of nuclear compartmentalization and has been shown to exert
multiple roles in cellular metabolism besides its main function as the place of rRNA …
multiple roles in cellular metabolism besides its main function as the place of rRNA …
METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation
Nucleoli are fundamentally essential sites for ribosome biogenesis in cells and formed by
liquid-liquid phase separation (LLPS) for a multilayer condensate structure. How the nucleoli …
liquid-liquid phase separation (LLPS) for a multilayer condensate structure. How the nucleoli …