Dynamic role of phospholipases A2 in health and diseases in the central nervous system

GY Sun, X Geng, T Teng, B Yang, MK Appenteng… - Cells, 2021 - mdpi.com
Phospholipids are major components in the lipid bilayer of cell membranes. These
molecules are comprised of two acyl or alkyl groups and different phospho-base groups …

Yin-Yang mechanisms regulating lipid peroxidation of docosahexaenoic acid and arachidonic acid in the central nervous system

B Yang, KL Fritsche, DQ Beversdorf, Z Gu… - Frontiers in …, 2019 - frontiersin.org
Phospholipids in the central nervous system (CNS) are rich in polyunsaturated fatty acids
(PUFAs), particularly arachidonic acid (ARA) and docosahexaenoic acid (DHA). Besides …

Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota

RM Golonka, X Xiao, AA Abokor, B Joe… - The Journal of nutritional …, 2020 - Elsevier
The metabolism of macro-and micronutrients is a complex and highly regulated biological
process. An imbalance in the metabolites and their signaling networks can lead to …

Effects of docosahexaenoic acid and its peroxidation product on amyloid-β peptide-stimulated microglia

X Geng, B Yang, R Li, T Teng, MJ Ladu, GY Sun… - Molecular …, 2020 - Springer
Growing evidence suggests that docosahexaenoic acid (DHA) exerts neuroprotective
effects, although the mechanism (s) underlying these beneficial effects are not fully …

Association between peripheral blood levels of vitamin A and Autism spectrum disorder in children: a meta-analysis

N Wang, Y Zhao, J Gao - Frontiers in Psychiatry, 2021 - frontiersin.org
Vitamin A is an essential fat-soluble micronutrient that plays important roles in a surprisingly
wide variety of biological processes from early growth and development to brain …

Effects of DHA (omega-3 fatty acid) and estradiol on amyloid β-peptide regulation in the brain

D Majou, AL Dermenghem - Brain research, 2024 - Elsevier
In the early stages of sporadic Alzheimer's disease (SAD), there is a strong correlation
between memory impairment and cortical levels of soluble amyloid-β peptide oligomers …

Protective effects of Clostridium butyricum against oxidative stress induced by food processing and lipid-derived aldehydes in Caco-2 cells

J Li, H Shen, Z Zhao, D Cao, M Zeng, H Cai… - Applied Microbiology …, 2020 - Springer
The human body is almost always facing the oxidative stress caused by foodborne
aldehydes such as glyoxal (GO) and methylglyoxal (MGO), 4-hydroxyhexenal (HHE), and 4 …

New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration

E Moine, M Boukhallat, D Cia, N Jacquemot… - Free Radical Biology …, 2021 - Elsevier
Dry age-related macular degeneration and Stargardt disease undergo a known toxic
mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for …

Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury

G Ungerer, J Cui, T Ndam, M Bekemeier, H Song… - Neuromolecular …, 2020 - Springer
Spinal cord injury (SCI) is a deliberating disorder with impairments in locomotor deficits and
incapacitating sensory abnormalities. Harpagophytum procumbens (Hp) is a botanical …

Quantitative proteomics reveals docosahexaenoic acid-mediated neuroprotective effects in lipopolysaccharide-stimulated microglial cells

B Yang, R Li, PN Liu, X Geng, BP Mooney… - Journal of proteome …, 2020 - ACS Publications
The high levels of docosahexaenoic acid (DHA) in cell membranes within the brain have led
to a number of studies exploring its function. These studies have shown that DHA can …