Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

A Lonardo, S Bellentani, CK Argo, S Ballestri… - Digestive and Liver …, 2015 - Elsevier
An improved understanding of non-alcoholic fatty liver disease epidemiology would lead to
identification of individuals at high risk of developing chronic liver disease and extra-hepatic …

[HTML][HTML] Genetic and epigenetic factors determining NAFLD risk

W Jonas, A Schürmann - Molecular metabolism, 2021 - Elsevier
Background Hepatic steatosis is a common chronic liver disease that can progress into more
severe stages of NAFLD or promote the development of life-threatening secondary diseases …

Genetic factors that affect risk of alcoholic and nonalcoholic fatty liver disease

QM Anstee, D Seth, CP Day - Gastroenterology, 2016 - Elsevier
Genome-wide association studies and candidate gene studies have informed our
understanding of factors contributing to the well-recognized interindividual variation in the …

Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies

J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2

QM Anstee, CP Day - Seminars in liver disease, 2015 - thieme-connect.com
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum that spans simple
steatosis, through nonalcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis …

Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment

P Dongiovanni, QM Anstee… - Current pharmaceutical …, 2013 - ingentaconnect.com
Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver
disease (NAFLD) which, when associated with oxidative hepatocellular damage …

Nonalcoholic fatty liver disease in children: unique considerations and challenges

D Goldner, JE Lavine - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence in concert with the
global epidemic of obesity and is being diagnosed at increasingly younger ages. The …

Comparison of the phenotype and approach to pediatric vs adult patients with nonalcoholic fatty liver disease

V Nobili, A Alisi, KP Newton, JB Schwimmer - Gastroenterology, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is one of the main chronic noncommunicable
diseases in Westernized societies; its worldwide prevalence has doubled during the last 20 …