Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles
in stem-cell identity, differentiation and disease. Mechanistically, they function within …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …

Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene
repression. Organized within multiprotein complexes, they regulate developmental genes in …

Polycomb group proteins are essential regulators of cell fate decisions during
embryogenesis. In mammals, at least five different Cbx proteins (Cbx2, Cbx4, Cbx6, Cbx7 …

The balance between self-renewal and differentiation of adult stem cells is essential for
tissue homeostasis. Here we show that in the haematopoietic system this process is …

The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-
renewing stem cells, which makes them vulnerable to physical and chemical insults …

Transcription factors comprise just over 7% of the human proteome and serve as
gatekeepers of cellular function, integrating external signal information into gene expression …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …