Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Death of adult cardiac myocytes and supportive tissues resulting from cardiovascular
diseases such as myocardial infarction is the proximal driver of pathological ventricular …

c-Kit, a type III receptor tyrosine kinase (RTK), is involved in multiple intracellular signaling
whereby it is mainly considered a stem cell factor receptor, which participates in vital …

Rationale: Although rare cardiomyogenesis is reported in the adult mammalian heart,
whether this results from differentiation or proliferation of cardiomyogenic cells remains …

Our previous studies showed that the combination of atorvastatin (ATV) and single injection
of ATV-pretreated mesenchymal stem cells (MSCs)(ATV-MSCs) at 1 week post-acute …

The heart is a metabolic omnivore and the adult heart selects the substrate best suited for
each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy …

Cardiovascular diseases remain the leading cause of death in the developed world,
accounting for more than 30% of all deaths. In a large proportion of these patients, acute …

The explosion of stem cell research in the past several years has made its presence known
in the field of cardiology and has been recently tasked with solving one of the largest health …

A, Stem cell antigen 1 (Sca-1)+ CD31+ cells isolated from Sca-1mCmR26tdTomato hearts
demonstrated successful recombination after tamoxifen induction (right) without leakiness in …