The intersection of the nervous system and breast cancer

Y Liu, S Yin, G Lu, Y Du - Cancer Letters, 2024 - Elsevier
Breast cancer (BC) represents a paradigm of heterogeneity, manifesting as a spectrum of
molecular subtypes with divergent clinical trajectories. It is fundamentally characterized by …

[HTML][HTML] Improving cancer immunotherapy by preventing cancer stem cell and immune cell linking in the tumor microenvironment

D Li, L Wang, B Jiang, Y Jing, X Li - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Cancer stem cells are the key link between malignant tumor progression and drug
resistance. This cell population has special properties that are different from those of …

Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

P Perampalam, JI MacDonald, K Zakirova, DT Passos… - Elife, 2024 - elifesciences.org
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a
prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive …

MDSCs in bone metastasis: mechanisms and therapeutic potential1

Z Li, Q Xia, Y He, L Li, P Yin - Cancer Letters, 2024 - Elsevier
Bone metastasis (BM) is a frequent complication associated with advanced cancer that
significantly increases patient mortality. Myeloid-derived suppressor cells (MDSCs) play a …

MicroRNA-34a negatively regulates Netrin1 and mediates MEK/ERK pathway to regulate chemosensitivity of gastric cancer cells

H Liu, L Wang - Discover Oncology, 2024 - Springer
Objective To explore the mechanism of action of MicroRNAs-34a (miR-34a) and Eurite
growth guiding factor 1 (Netrin1) in cisplatin resistance in gastric cancer (GC), providing new …

Research progress of the netrins and their receptors in cancer

X Gao, J Ye, X Huang, S Huang, W Luo… - Journal of Cellular …, 2024 - Wiley Online Library
Netrins, a family of secreted and membrane‐associated proteins, can regulate axonal
guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis …

Periampullary cancer and neurological interactions: current understanding and future research directions

Y Wang, Z Liu, Y Tian, H Zhao, X Fu - Frontiers in Oncology, 2024 - frontiersin.org
Periampullary cancer is a malignant tumor occurring around the ampullary region of the liver
and pancreas, encompassing a variety of tissue types and sharing numerous biological …

Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer

S Breusa, E Thomas, N Baldinotti, S Zilio… - Biomaterials …, 2024 - Elsevier
Nanoparticle's success as drug delivery systems for cancer treatment has been achieved
through passive targeting mechanisms. However, tumor heterogeneity and rapid drug …

[HTML][HTML] IL-13Rα2 Is Involved in Resistance to Doxorubicin and Survival of Osteosarcoma Patients

M Karamikheirabad, J Zhang, AR Ahn, HS Park… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Interleukin 13 receptor alpha 2 (IL-13Rα2) is a receptor with a high
affinity for IL-13 and is involved in the progression of human cancers. However, studies on …

Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

K Wang, Y Wang, K Yin - Journal of Cancer Research and Clinical …, 2024 - Springer
Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide.
Numerous studies have demonstrated the significance of myeloid-derived suppressor cells …